Hypolipidemic alkoxybenzoic acids was written by DeVries, Vern G.;Moran, Daniel B.;Allen, George R.;Riggi, Stephen J.. And the article was included in Journal of Medicinal Chemistry in 1976.SDS of cas: 56523-59-2 This article mentions the following:
A series of â?0 p-alkoxybenzoic acids (I) with aromatic ring substituents or modified alkyl or unsaturated chains (R1), prepared by alkylation of the appropriate hydroxybenzoate ester followed by saponification, was screened in rats for serum-sterol and triglyceride lowering activity. Alkyl chain substituents such as chloro and oximino enhanced activity, while azido, thiol, and some alkylthio groups resulted in retention of activity. Some alkylthio substituents on the alkyl chain and aryl ring substituents abolished sterol-lowering activity. The effect of alkyl chain branching was variable, while unsaturation had no adverse effect on activity except when located near either end of the chain. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2SDS of cas: 56523-59-2).
15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.SDS of cas: 56523-59-2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary