Adding a certain compound to certain chemical reactions, such as: 101417-40-7, name is 4-(Bromomethyl)benzo[d][1,3]dioxole, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101417-40-7, Quality Control of 4-(Bromomethyl)benzo[d][1,3]dioxole
7.5 g (0.033 mol) of 2,3-dimethoxymethylene benzyl bromide,4.5 g (0.036 mol) of m-hydroxybenzaldehyde and 13.5 g (0.099 mol) of potassium carbonate were dissolved in 80 ml of DMF.The reaction was stirred overnight at 40C. After the reaction was stopped, it was filtered after the temperature was lowered to room temperature.An equal volume of water and ethyl acetate were added to the filtrate and the layers were separated. The aqueous phase was extracted twice with ethyl acetate.The organic phases were combined and washed in the order of saturated sodium bicarbonate solution-water-saturated brine.Anhydrous sodium sulfate was dried for 8 h. The desiccant was filtered off, the solvent was evaporated under reduced pressure, and the residue was separated by silica gel column chromatography.Elution with petroleum ether:ethyl acetate (10:1) to collect the desired components,Evaporation under reduced pressure gave a white solid VId 6.3 g, yield 74.8%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Bromomethyl)benzo[d][1,3]dioxole, and friends who are interested can also refer to it.
Reference:
Patent; The Chinese People’s Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute; Zhong Bohua; Zhang Ping; He Xinhua; Shi Weiguo; Fan Shiyong; Yao Yishan; Jia Hongxin; (20 pag.)CN103804341; (2018); B;,
Bromide – Wikipedia,
bromide – Wiktionary