Sriram, D. published the artcileNovel pthalazinyl derivatives: synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis isocitrate lyase enzyme, Formula: C7H5Br2F, the publication is Medicinal Chemistry (2009), 5(5), 422-433, database is CAplus and MEDLINE.
Novel 2-[3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydro-1-phthalazinyl]acetic acid hydrazones were synthesized from phthalic anhydride by a six step synthesis and evaluated for in vitro, in vivo activities against eight mycobacterial species and Mycobacterium tuberculosis (MTB) isocitrate lyase (ICL) enzyme inhibition studies. Among twenty six compounds N’1-[(4-nitrophenyl)methylene]-2-[3-(4-bromo-2-fluorobenzyl)-4-oxo-1,2,3,4-tetrahydro-1-phthalazinyl]ethanohydrazide (I) was found to be the most active compound in-vitro with MIC’s of 0.18 and <0.09 μM against log-phase cultures of MTB and multi-drug resistant MTB resp. Compound I inhibited all the eight mycobacterial species with MIC ranging from <0.09-12.25 μM and was not toxic to Vero cell lines till 122.5 μM. Seven compounds were tested against starved culture of MTB and they inhibited with MIC’s ranging from 2.88-8.91 μM. Some compounds showed 45-61% inhibition against MTB ICL enzyme at 10 μM. In the in vivo animal model I decreased the bacterial load in lung and spleen tissues with 1.87 and 3.03-log10 protections resp. at 25 mg/kg body weight dose.
Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C16H20N2, Formula: C7H5Br2F.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary