Dutta, Shubham published the artcileKeteniminium-Driven Umpolung Difunctionalization of Ynamides, Application In Synthesis of 1228180-83-3, the publication is Angewandte Chemie, International Edition (2020), 59(27), 10785-10790, database is CAplus and MEDLINE.
A three-component Pd-catalyzed coupling of ynamides, aryl diazonium salts, and aryl boronic acids for the synthesis of novel triaryl-substituted enamides is described. This transformation represents the first example of an umpolung regioselective unsym. syn-1,2-diarylation/aryl-olefination of ynamides. The aryl moieties of the diazonium salt (electrophile) and boronic acid (nucleophile) are explicitly incorporated in the electrophilic α- and nucleophilic β-position, resp., of the ynamide, resulting in a single isomer of the N-bearing tetrasubstituted olefin. The scope is broad (68 examples), showing excellent functional-group tolerance. DFT calculations substantiate the rationale of the mechanistic cycle and the regioselectivity. The chemoselectivity and synthetic potential of the enamide products were also studied.
Angewandte Chemie, International Edition published new progress about 1228180-83-3. 1228180-83-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Boronic Acids, name is 3,4-Dibromophenylboronic acid, and the molecular formula is C6H5BBr2O2, Application In Synthesis of 1228180-83-3.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary