Synthetic Route of 1435-51-4, These common heterocyclic compound, 1435-51-4, name is 1,3-Dibromo-5-fluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
According to the reaction formula (2), the specific steps are: in a nitrogen atmosphere,Tris (dibenzylideneacetone) dipalladium (0.4mmol), tri-tert-butylphosphorus (1.2mmol),1-Fluoro-3,5-dibromobenzene (10 mmol) and diphenylamine (22 mmol) were dispersed in anhydrous toluene (80 mL), heated to reflux (110 C.) and reacted at this temperature for 16 h. After the reaction system is cooled to room temperature, the reaction solution is diluted, and the diluted reaction solution is suction-filtered with a Buchner funnel covered with silica gel, and the solution is concentrated at a low pressure, and then a mixture of dichloromethane and n-hexane is used in a volume ratio of 1: 1. Silica gel column chromatography was performed as the eluent to obtain di-tertiary amine compound 1a in a yield of 94%.
The synthetic route of 1435-51-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Beijing University Shenzhen Sheng Yuan; Meng Hong; Shi Ming; Sun Yue; (24 pag.)CN110790782; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary