Synthetic Route of 3972-64-3, These common heterocyclic compound, 3972-64-3, name is 1-Bromo-3-(tert-butyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 36: 3-t-butyl benzaldehyde3-t-butyl phenylbromide was dissolved in THF and n-BuLi was added thereto, followed by addition of DMF and stirring at 0¡ãC for 3 hours. After the reaction was complete, NH4Cl was added to the reaction mixture, followed by extraction with EtOAc. The organic extract was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: EtOAc: n-Hex = 1/3) to afford the title compound (339 mg, 80percent).MS|M+1] = 163 (M+1)
The synthetic route of 3972-64-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG LIFE SCIENCES, LTD.; WO2009/38412; (2009); A2;,
Bromide – Wikipedia,
bromide – Wiktionary