Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 558-13-4, name is Carbontetrabromide, A new synthetic method of this compound is introduced below., Application In Synthesis of Carbontetrabromide
b 3-(Fluoro)phenethyl bromide To a solution of 3-(fluoro)phenethyl alcohol (3.8 g, 27.0 mmol), in anhydrous dichloromethane (100 ml), cooled to 0 C., was added carbon tetrabromide (11.25 g, 34.0 mmol) and triphenylphosphine (10.62 g, 41.0 mmol). After stirring for 0.5 h the solvent was removed in vacuo and diethyl ether (100 ml) was added to the residue. The resultant precipitate was removed by filtration, the filtrate evaporated under reduced pressure and the crude product chromatographed on silica-gel eluding with ethyl acetate/hexane (1:1) to give 3-(fluoro)phenethyl bromide (5.51 g, 100%), delta (250 MHz, CDCl3) 3.16 (2H, t, J=7.4 Hz, CH2), 3.57 (2H, t, J=7.4 Hz, CH2), 6.91-7.01 (3H, m, Ar–H), 7.24-7.33 (1H, m, Ar–H).
The synthetic route of 558-13-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Sharp & Dohme, Ltd.; US5889008; (1999); A;,
Bromide – Wikipedia,
bromide – Wiktionary