Yoakim, Christiane published the artcileβ-Lactam Derivatives as Inhibitors of Human Cytomegalovirus Protease, COA of Formula: C8H6BrF3S, the publication is Journal of Medicinal Chemistry (1998), 41(15), 2882-2891, database is CAplus and MEDLINE.
The development of novel monobactam inhibitors of HCMV protease incorporating a carbon side chain at C-4 and a urea function at N-1 is described. Substitution with small groups at the C-3 position of the β-lactam ring gave an increase in enzymic activity and in stability; however, a lack of selectivity against other serine proteases was noted. The use of both tri- and tetrasubstituted urea functionalities gave effective inhibitors of HCMV protease. Benzyl substitution of the urea moiety was beneficial, especially when strong electron-withdrawing groups where attached at the para position. Modest antiviral activity was found in a plaque reduction assay.
Journal of Medicinal Chemistry published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C9H8BNO2, COA of Formula: C8H6BrF3S.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary