Related Products of 656-64-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 656-64-4, name is 3-Bromo-4-fluoroaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 7. 2′,6-Difluoro-5′-(5-(2-hvdroxypropan-2-yl -lH-benzor(ilimidazoll- yl)biphenyl-2-carbonitrile (Compound 111).Scheme 18. Preparation of Compound 111.[168] Step 1. l-(4-(3-Bromo-4-fluorophenylaminoV3-nitrophenyl ethanone (31): 30 (5 g, 27.3 mmol) was mixed with 3-bromo-4-fluoroaniline (8.3 g, 44 mmol) in NMP (20 mL) and heated at 90 C. After 3 days the reaction was cooled and the mixture was poured into ice water (500 mL). The orange solid was filtered, washed with water (200 mL) and then washed with heptanes (100 mL). After drying under vacuum for 6 hours at 50 C, 11.2 g (>100%) of 31 was obtained. The sample contained residual NMP by NMR and was used directly in the next step.
The synthetic route of 3-Bromo-4-fluoroaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CONCERT PHARMACEUTICALS, INC.; LIU, Julie, F.; HARBESON, Scott, L.; WO2011/47315; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary