Adding a certain compound to certain chemical reactions, such as: 50670-49-0, name is 4-Bromo-4′-methyl-1,1′-biphenyl, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50670-49-0, SDS of cas: 50670-49-0
General procedure: To a 100 mL two neck round-bottomflaskwere added compound 4c(500.0 mg, 1.0 eq), p-anisidine (287.2 mg, 1.2 eq), Pd2(dba)3 (35.6 mg,0.02 eq), t-BuONa (280.1 mg, 1.5 eq), P(t-Bu)3 (7.9 mg, 0.02 eq) and 10 mL anhydrous toluene. The reaction mixture was refluxed 12 hunder argon. After cooling down to room temperature, the mixturewas exacted with ethyl acetate and washed with water. The organiclayer was dried over anhydrous Na2SO4, filtered, and concentrated invacuum to give the crude product, which was purified by column chromatograph packed with silica gel using petroleum ether (PE)-ethyl acetate (EA) (100:1) as the eluent to afford pure compound 5c. 5a: gray soild (421.2 mg, 72%), 1H NMR (400 MHz, DMSO) delta 7.99 (s,1H), 7.48 (d, J=2.7 Hz, 2H), 7.46 (d, J=3.2 Hz, 2H), 7.21 (d, J=7.9 Hz,2H), 7.08 (d, J=8.9 Hz, 2H), 6.98 (d, J=8.7 Hz, 2H), 6.89 (d, J=8.9 Hz,2H), 3.72 (s, 3H), 2.31 (s, 3H).
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Reference:
Article; Li, Fusheng; Zhao, Baodong; Chen, Yu; Zhang, Yufei; Wang, Tao; Xue, Song; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 185; (2017); p. 20 – 26;,
Bromide – Wikipedia,
bromide – Wiktionary