Wiskur, Sheryl L.’s team published research in Organic Letters in 3 | CAS: 166821-88-1

Organic Letters published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C8H8O3, Synthetic Route of 166821-88-1.

Wiskur, Sheryl L. published the artcilepKa Values and Geometries of Secondary and Tertiary Amines Complexed to Boronic Acids-Implications for Sensor Design, Synthetic Route of 166821-88-1, the publication is Organic Letters (2001), 3(9), 1311-1314, database is CAplus and MEDLINE.

The pKa values and the geometries of secondary and tertiary amines adjacent to boronic acids (e.g. 2-(PhCH2NRCH2)C6H4B(OH)2; R = H, Me) were determined using potentiometric and 11B NMR titrations The studies showed that the secondary ammonium ion has a pKa similar to that of the tertiary ammonium species, which gives tetrahedral B centers at pH values ≳5.5. Therefore, secondary amines as well as tertiary amines, when placed proximal to B centers, can be used to create tetrahedral boronic acids at neutral pH for diol complexation. The mol. structure of 2,6-(2-(2-((HO)2B)C6H4CH2NHCH2)-4-pyrimidinyl)2pyridine was determined by x-ray crystallog.

Organic Letters published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C8H8O3, Synthetic Route of 166821-88-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary