Braude, Irwin A. published the artcileMechanism of interaction of sodium dodecyl sulfate with mouse interferon, Synthetic Route of 518-67-2, the publication is Journal of Biological Chemistry (1979), 254(16), 7758-64, database is CAplus and MEDLINE.
Na dodecyl sulfate (SDS) and other alkyl sulfates, provided they contained a min. of 12 C atoms (or ≥22 Å in length), stabilized mouse interferon (MIF) in the presence of urea, 2-mercaptoethanol, and heat. When MIF was treated with the alkyl sulfates in the absence of urea and 2-mercaptoethanol, all alkyl sulfates inactivated MIF to the same extent, suggesting that the stabilizing effect of SDS on MIF most likely occurs during the refolding process. Unlike SDS, other amphiphiles such as dodecylamine, Li dodecyl sulfate, and Na 1-dodecane sulfonate did not have an appreciable stabilizing effect on MIF, thus emphasizing the necessity of specific counter-ions and polar groups for SDS to affect MIF stability. Subsequent to its reaction with SDS, MIF no longer was bound to controlled pore glass (CPG) beads. This is most likely due to SDS masking the protein’s silanol-binding sites. Furthermore, after it had reacted with interferon, a portion (∼20 to 50%) of the SDS was no longer retained by the anion exchange resin AG1-X10. Conversely, interferon (which does not bind to AG1-X2, a resin with a larger pore size than AG1-X10) was retained by the resin AG1-X2 after it has reacted with SDS. In addition, SDS-treated MIF was able to bind to the immobilized hydrophobic ligand hexyl-agarose under conditions where the majority of the MIF itself was not retained. Some SDS co-eluted with MIF from AG1-X10, indicating that SDS binds to MIF. Furthermore, since SDS-treated MIF was retained by AG1-X2 and hexyl-agarose, at least some of the detergent’s polar and hydrophobic regions are located at the surface of the interferon mol.
Journal of Biological Chemistry published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Synthetic Route of 518-67-2.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary