Adane, Legesse’s team published research in Bioorganic & Medicinal Chemistry Letters in 24 | CAS: 76283-09-5

Bioorganic & Medicinal Chemistry Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Application In Synthesis of 76283-09-5.

Adane, Legesse published the artcileDesign and synthesis of guanylthiourea derivatives as potential inhibitors of Plasmodium falciparum dihydrofolate reductase enzyme, Application In Synthesis of 76283-09-5, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(2), 613-617, database is CAplus and MEDLINE.

A new class of compounds, e.g. I [R = 3,4-(MeO)2C6H3; 3-PhC6H4, 4-CF3C6H4, etc.], based on S-benzylated guanylthiourea has been designed as potential Plasmodium falciparum dihydrofolate reductase inhibitors using computer aided methods (mol. electrostatic potential, mol. docking). Several compounds in this class have been synthesized starting from guanylthiourea and alkyl bromides. In vitro studies showed that two compounds from this class are active with the IC50 value of 100 μM and 400 nM.

Bioorganic & Medicinal Chemistry Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Application In Synthesis of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary