Dymock, Brian W. published the artcileNovel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design, Safety of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Journal of Medicinal Chemistry (2005), 48(13), 4212-4215, database is CAplus and MEDLINE.
The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of mol. chaperone Hsp90 has been used to design 5-amide analogs. These exhibit enhanced potency against the target in binding and functional assays with accompanying appropriate cellular pharmacodynamic changes. Compound 11 (VER-49009) compares favorably with the clin. evaluated 17-AAG.
Journal of Medicinal Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Safety of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary