Neu, Henrik published the artcileSynthesis of saturated fatty acids 11C(13C)-labeled in the ω-methyl position, Category: bromides-buliding-blocks, the main research area is fatty acid omega labeled preparation; zerovalent copper catalyst methylation.
A method for the preparation of ω-labeled saturated fatty acids 11C(13C)H3(CH2)nCO2H (n = 1,2,3,,6,10,14) is described. A highly reactive zerovalent copper complex was prepared from lithium naphthalenide reduced lithium(2-thienyl)iodocuprate. The labeling precursors were obtained by addition of tert-Bu ω-iodocarboxylates to the organocuprate and these were reacted with [11C]methyl iodide to form 11C-labeled, protected intermediates. The tert-Bu ester protecting group was rapidly removed with trifluoroacetic acid, affording fatty acids 11C-labeled in the ω-Me position. A solid phase extraction method was developed and preceded final HPLC purification In a typical run starting with 2.75 GBq of [11C]methyl iodide, 375 MBq (66%) [16-11C]palmitic acid was obtained within 46 min from the end of radionuclide production
Journal of Labelled Compounds & Radiopharmaceuticals published new progress about Methylation. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Category: bromides-buliding-blocks.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary