Rice, Kenneth D. published the artcilePyrazolopyrimidines as dual Akt/p70S6K inhibitors, SDS of cas: 74896-66-5, the main research area is pyrazolopyrimidine preparation Akt p70S6K inhibitor SAR.
Activation of the PI3K/Akt/mTOR kinase pathway is frequently associated with human cancer. Selective inhibition of p70S6 Kinase, which is the last kinase in the PI3K pathway, is not sufficient for strong tumor growth inhibition and can lead to activation of upstream proteins including Akt through relief of a neg. feedback loop. Targeting multiple sites in the PI3K pathway might be beneficial for optimal activity. In this manuscript we report the design of dual Akt/p70S6K inhibitors and the evaluation of the lead compound 11b (I) in vivo, which was eventually advanced into clin. development.
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, SDS of cas: 74896-66-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary