Reference of 55289-36-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55289-36-6, name is 3-Bromo-2-methylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of sodium sulfate (61 .1 g, 430 mmol), hydroxylamine hydrochloride (8.96 g, 129 mmol), 2,2,2-trichloro-1 -ethoxyethanol (9.98 g, 51 .6 mmol) and 3-bromo-2- methylaniline (8 g, 43 mmol) in water (300 ml_) was added hydrochloric acid (3.92 ml_, 129 mmol) slowly. This mixture was heated to 90 C for 1 hr. The reaction was cooled, filtered and the solid was washed with water and dried to give 6-bromo-7- methylindoline-2,3-dione (8.6g, 35.8 mmol, 83 % yield) as a brown solid.
The synthetic route of 3-Bromo-2-methylaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; JIN, Qi; POHLHAUS, Denise Teotico; SPLETSTOSER, Jared; (320 pag.)WO2017/98440; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary