Liu, Jing published the artcileIdentification and Elimination of an Unexpected Catalyst Poison in Suzuki Coupling, Safety of 5-Bromo-6-hydroxynicotinic acid, the main research area is unexpected Suzuki coupling catalyst poison sulfur free synthesis.
A Suzuki coupling reaction gave an uncharacteristically low conversion in a GMP campaign. Initial investigation revealed a palladium catalyst poison in the starting material. A temporary solution was developed along with contingency plans to enable successful material delivery. Further systematic studies led to the identification of elemental sulfur as the culprit. A “”sulfur-free”” synthesis of the starting material was developed for the next round of manufacturing
Organic Process Research & Development published new progress about Polymerization catalysts (poisons). 41668-13-7 belongs to class bromides-buliding-blocks, name is 5-Bromo-6-hydroxynicotinic acid, and the molecular formula is C6H4BrNO3, Safety of 5-Bromo-6-hydroxynicotinic acid.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary