Zhang, Yun published the artcileChiral Phosphoric Acid Catalyzed Asymmetric Ugi Reaction by Dynamic Kinetic Resolution of the Primary Multicomponent Adduct, Related Products of bromides-buliding-blocks, the main research area is chiral phosphoric acid catalyzed asym Ugi dynamic kinetic resolution; enantioselective synthesis aryloxoisoindolinecarboxamide; formylbenzoic acid aniline isonitrile asym Ugi reaction; asymmetric synthesis; kinetic resolution; multicomponent reaction; organocatalysis; reaction mechanisms.
Reaction of isonitriles with 3-(arylamino)isobenzofuran-1(3H)-ones in the presence of a catalytic amount of an octahydro (R)-binol-derived chiral phosphoric acid afforded 3-oxo-2-arylisoindoline-1-carboxamides in high yields with good to high enantioselectivities [e.g., I + tert-BuNC → II (93% yield, 87% ee)]. An enantioselective Ugi four-center three-component reaction of 2-formylbenzoic acids, anilines, and isonitriles was subsequently developed for the synthesis of the same heterocycle. Mechanistic studies indicate that the enantioselectivity results from the dynamic kinetic resolution of the primary Ugi adduct, rather than from the C-C bond-forming process. The resulting heterocycle products are of significant medicinal importance.
Angewandte Chemie, International Edition published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Related Products of bromides-buliding-blocks.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary