Wang, Qian published the artcileIsoquinolone-4-Carboxylic Acids by Ammonia-Ugi-4CR and Copper-Catalyzed Domino Reaction, Category: bromides-buliding-blocks, the main research area is carboxy isoquinolone preparation green chem; benzoylaminoacetamide preparation green chem keto ester heterocyclization copper catalyst; halobenzoic acid aldehyde isocyanide ammonia multicomponent Ugi reaction.
Highly substituted isoquinolone-4-carboxylic acid I (R1 = H, 7-Me, 6-OMe, 6-NO2, etc.; R2 = H, Me, cyclopentyl, Ph, etc.; R3 = tert-Bu, 2-ethylphenyl, cyclopropylmethyl, benzyl, etc.; R4 = Me, iso-Pr, Pr, phenyl) is an important bioactive scaffold; however, it is challenging to access it in a general and short way. A Cu-catalyzed cascade reaction was successfully designed involving the Ugi postcyclization strategy by using ammonia and 2-halobenzoic acids 2-X-(R5)C6H3C(O)OH (R5 = H, 4-OMe, 5-Me, etc.; X = Br, I) as crucial building blocks. Privileged polysubstituted isoquinolin-1(2H)-ones I were constructed in a combinatorial format with generally moderate to good yields. The protocol, with a ligand-free catalytic system, shows a broad substrate scope and good functional group tolerance toward excellent mol. diversity. Free 4-carboxy-isoquinolone is now for the first time generally accessible by a convergent multicomponent reaction protocol.
Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Category: bromides-buliding-blocks.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary