Related Products of 460-00-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 460-00-4, name is 1-Bromo-4-fluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: 7a was prepared by reacting compound 6 (4.00g, 18.1mmol) with 4-bromoanisole (3.38g, 18.1mmol) in the presence of Pd(PPh3)4 and Na2CO3 (6.40g, 60mmol) in THF (80mL containing 10% water). After refluxing for 15h at 368K, the product was extracted with CH2Cl2. The organic layer was dried over MgSO4, filtrated, and evaporated. Column chromatography on SiO2 with petroleum ether as the eluent afforded 3.99g of 7a as a yellowish solid in 78% yield.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-fluorobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Liu, Hongliang; Pu, Shouzhi; Liu, Gang; Chen, Bing; Dyes and Pigments; vol. 102; (2014); p. 159 – 168;,
Bromide – Wikipedia,
bromide – Wiktionary