In 2022,Li, Changhao; He, Qiaobian; Xu, Yuwen; Lou, Hongxiang; Fan, Peihong published an article in ACS Omega. The title of the article was 《Synthesis of 3-O-Acetyl-11-keto-β-boswellic Acid (AKBA)-Derived Amides and Their Mitochondria-Targeted Antitumor Activities》.HPLC of Formula: 17696-11-6 The author mentioned the following in the article:
In this study, the authors synthesized a series of amide and mitochondria-targeted derivatives with 3-O-acetyl-11-keto-β-boswellic acid (AKBA) as the parent structure and an ethylenediamine moiety as the link chain. Compound I, a mitochondrial-targeting potential derivative, showed significantly stronger antitumor activity than that of AKBA, and it could induce vacuolization of A549 cells and stimulate the production of reactive oxygen species (ROS) in a time- and concentration-dependent manner. The antioxidant N-acetylcysteine (NAC) could inhibit the ROS level but could not suppress vacuolization and cell death induced by I. Further studies demonstrated that I caused abnormal opening of mitochondrial permeability transition pore (MPTP) and a decrease of mitochondrial membrane potential; addnl., it caused cell cycle arrest in G0/G1 but did not induce apoptosis. I represents a compound with improved antiproliferative effects for cancer therapy working through new mechanisms. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6HPLC of Formula: 17696-11-6)
8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.HPLC of Formula: 17696-11-6
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary