The author of 《NCα-gem-dimethylated peptoid side chains: A novel approach for structural control and peptide sequence mimetics》 were Shyam, Radhe; Nauton, Lionel; Angelici, Gaetano; Roy, Olivier; Taillefumier, Claude; Faure, Sophie. And the article was published in Biopolymers in 2019. Application of 5437-45-6 The author mentioned the following in the article:
The design of linear peptoid oligomers adopting well-defined secondary structures while mimicking defined peptide primary sequences is a major challenge in the context of drug discovery. To this end, chemists have developed cis-inducing peptoid side chains to build robust polyproline type I helixes. However, the number of efficient examples remains scarce and chem. diversity accessible through the use of these side chains is limited. Herein, we introduce an array of NCα-gem-dimethylated peptoid residues mimicking proteinogenic amino acids. Submonomer synthesis and block-coupling approaches were explored to access heterooligomers incorporating these novel types of side chains. NMR studies of monomer and trimer models showed that the NCα-gem-dimethylated groups exert complete cis control on the backbone amide conformation. Lastly, a preliminary mol. modeling study gave an insight into the preferred orientation of the substituents of the NCα-gem-dimethyl side chains relative to the peptoid backbone. After reading the article, we found that the author used Benzyl 2-bromoacetate(cas: 5437-45-6Application of 5437-45-6)
Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Application of 5437-45-6
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary