In 2019,Organic Letters included an article by Sun, Song; Zhou, Cong; Yu, Jin-Tao; Cheng, Jiang. Application In Synthesis of (Bromomethyl)cyclopropane. The article was titled 《Visible-Light-Driven Palladium-Catalyzed Oxy-Alkylation of 2-(1-Arylvinyl)anilines by Unactivated Alkyl Bromides and CO2: Multicomponent Reactions toward 1,4-Dihydro-2H-3,1-benzoxazin-2-ones》. The information in the text is summarized as follows:
A visible-light-driven palladium-catalyzed radical oxy-alkylation of 2-(1-arylvinyl)anilines with unactivated alkyl bromides and CO2 was developed toward 1,4-dihydro-2H-3,1-benzoxazin-2-ones. This multicomponent reaction (MCR) starts with (1) carboxylation of an amino by CO2; (2) formation of Pd(I) and an alkyl radical via visible-light-driven reaction of alkyl bromides and Pd(0); (3) addition of an alkyl radical to the vinyl followed by single electron transfer (SET) oxidation to the carbocation by Pd(I); and (4) cyclization via intramol. nucleophilic attack of the carboxylate anion to carbocation. The experimental part of the paper was very detailed, including the reaction process of (Bromomethyl)cyclopropane(cas: 7051-34-5Application In Synthesis of (Bromomethyl)cyclopropane)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application In Synthesis of (Bromomethyl)cyclopropane
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary