《Efficient Synthesis of Hydroxy-Substituted 2-Aminobenzo[d]thiazole-6-carboxylic Acid Derivatives as New Building Blocks in Drug Discovery》 was written by Durcik, Martina; Toplak, Zan; Zidar, Nace; Ilas, Janez; Zega, Anamarija; Kikelj, Danijel; Masic, Lucija Peterlin; Tomasic, Tihomir. Application In Synthesis of Methyl 3-(bromomethyl)benzoate And the article was included in ACS Omega in 2020. The article conveys some information:
Benzo[d]thiazole is widely used in synthetic and medicinal chem., and it is a component of many compounds and drugs that have several different bioactivities. Herein, an elegant pathway for synthesis of Me 4- and 5-hydroxy-2-amino-benzo[d]thiazole-6-carboxylates as building blocks that can be substituted at four different positions on the bicycle has been described and thus offer the possibility to thoroughly explore the chem. space around the mol. studied as a ligand for the chosen target. A series of 12 new compounds was prepared using the described methods and Williamson ether synthesis.Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application In Synthesis of Methyl 3-(bromomethyl)benzoate) was used in this study.
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Application In Synthesis of Methyl 3-(bromomethyl)benzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary