In 2019,Synthesis included an article by Iskryk, Marharyta; Barysevich, Maryia; Oseka, Maksim; Adamson, Jasper; Kananovich, Dzmitry. Synthetic Route of C7H13BrO2. The article was titled 《Asymmetric Kulinkovich Hydroxycyclopropanation of Alkenes Mediated by Titanium(IV) TADDOLate Complexes》. The information in the text is summarized as follows:
Asym. Kulinkovich cyclopropanation of carboxylic esters with prochiral alkenes was reported. The process was mediated by titanium(IV) (4R,5R)-TADDOLate complexes and afforded correspondingly (Z)- or (E)-cyclopropanols with up to 84-87% ee in the event of intra- or intermol. olefin ligand exchange in intermediate titanacyclopropane [titanium(II)-alkene] species. Configuration of the olefin double bond was preserved in the cyclopropane products, pointing out on total retention of configuration at Ti-C bond in the cyclopropane forming step. The results were interpreted in the framework of ate complex mechanism, suggesting formation of pentacoordinated titanium ate species as a prerequisite of high enantiocontrol. The experimental part of the paper was very detailed, including the reaction process of Ethyl 5-bromovalerate(cas: 14660-52-7Synthetic Route of C7H13BrO2)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Synthetic Route of C7H13BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary