In 2022,Zhang, Gong; Zhao, Chao-Yang; Min, Xiang-Ting; Li, Ying; Zhang, Xiang-Xin; Liu, Heng; Ji, Ding-Wei; Hu, Yan-Cheng; Chen, Qing-An published an article in Nature Catalysis. The title of the article was 《Nickel-catalysed asymmetric heteroarylative cyclotelomerization of isoprene》.Recommanded Product: 7051-34-5 The author mentioned the following in the article:
Monoterpenoids are a class of isoprenoids produced from geranyl diphosphate by various monoterpene synthases. Nature has evolved over millions of years to produce various cyclic monoterpenoids. Herein, authors present a serendipitous creation of an unnatural monoterpene skeleton through heteroarylative telomerization of isoprene with heterocycles. Under nickel catalysis, a series of cyclic monoterpene derivatives bearing quaternary carbon stereocentre are constructed with up to 98% yield and 97% enantiomeric excess. Preliminary mechanistic studies suggest this atom-economic reaction proceeds through an enantioselective dimerization of isoprene and a sequential C-H alkylation of heterocycles pathway. This work not only contributes an efficient enantioselective transformation of bulk chem. isoprene, but also provides a guide to create an unnatural monoterpene framework that may exhibit different biol. activities. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: 7051-34-5)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: 7051-34-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary