Wu, Chongyang; Ying, Tao; Yang, Xinjie; Su, Weike; Dushkin, Alexandr V.; Yu, Jingbo published their research in Organic Letters in 2021. The article was titled 《Mechanochemical Magnesium-Mediated Minisci C-H Alkylation of Pyrimidines with Alkyl Bromides and Chlorides》.Formula: C4H7Br The article contains the following contents:
A novel method to synthesize 4-alkylpyrimidines by the mechanochem. magnesium-mediated Minisci reaction of pyrimidine derivatives and alkyl halides was reported. The reaction process operated with a broad substrate scope and excellent regioselectivity under mild conditions with no requirement of transition-metal catalysts, solvents, and inert gas protection. The practicality of this protocol was demonstrated by the up-scale synthesis, mechanochem. product derivatization and preparation of the antimalarial drug pyrimethamine. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5Formula: C4H7Br)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Formula: C4H7Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary