In 2022,Ado, Genyir; Noda, Naotaka; Vu, Hue T.; Perron, Amelie; Mahapatra, Amarjyoti D.; Arista, Karla Pineda; Yoshimura, Hideaki; Packwood, Daniel M.; Ishidate, Fumiyoshi; Sato, Shin-ichi; Ozawa, Takeaki; Uesugi, Motonari published an article in Chemical Science. The title of the article was 《Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells》.Related Products of 14660-52-7 The author mentioned the following in the article:
Phase-separated membraneless organelles or biomol. condensates play diverse functions in cells, however recapturing their characteristics using small organic mols. has been a challenge. In the present study, cell-lysate-based screening of 843 self-assembling small mols. led to the discovery of a simple organic mol., named huezole, that forms liquid droplets to selectively sequester tubulin. Remarkably, this small mol. enters cultured human cells and prevents cell mitosis by forming tubulin-concentrating condensates in cells. The present study demonstrates the feasibility of producing a synthetic condensate out of non-peptidic small mols. for exogenous control of cellular processes. The modular structure of huezole provides a framework for designing a class of organelle-emulating small mols. The experimental part of the paper was very detailed, including the reaction process of Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 14660-52-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary