2550-36-9, name is (Bromomethyl)cyclohexane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C7H13Br
Step 1 : Ethyl 1-(cvclohexylmethyl)-5-methyl-1 H-pyrrole-2-carboxylate (1a)A solution of ethyl 5-methyl-1 –pyrrole-2-carboxylate (15.0 g, 98.0 mmol), (bromo- methyl)cyclohexane (17.6 g, 100 mmol) and K2C03 (41.4 g, 300 mmol) in dry DMF (150 mL) was stirred at 50C overnight, then cooled to rt and filtered. To the filtrate was added NaH (12.0 g, 60%, 300 mmol) slowly. Then the mixture was stirred overnight at 50C. The reaction mixture was quenched with water and extracted with EA twice. The combined organic phases were washed with water (3 x) and brine (2 x), dried over Na2S04l filtered, concentrated and purified by CC (EA/PE = 1/20) to give compound 1a (19.9 g, 82%) as a white solid.
The synthetic route of 2550-36-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2012/139775; (2012); A1;,
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bromide – Wiktionary