The author of 《Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold》 were Li, Zheng; Ren, Qiang; Wang, Xuekun; Zhou, Zongtao; Hu, Lijun; Deng, Liming; Guan, Li; Qiu, Qianqian. And the article was published in Bioorganic Chemistry in 2019. Application of 7051-34-5 The author mentioned the following in the article:
Based on a previously reported phenoxyacetic acid scaffold, compound 7 (HWL-088) has been identified as a superior free fatty acid receptor 1 (FFA1) agonist by comprehensive structure-activity relationship study. Our results indicated that the introduction of ortho-fluoro greatly increased the activity of phenoxyacetic acid series, and the unique structure-activity relationship in biphenyl moiety is different from previously reported FFA1 agonists. Moreover, the modeling study was also performed to better understand the binding mode of present series. Compound 7 significantly improved glucose tolerance both in normal and diabetic models, and even exerted greater potential on glucose control than that of TAK-875. These findings provided a novel candidate HWL-088, which is currently in preclin. study to evaluate its potential for the treatment of diabetes. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary