Qiu, Shaotong; Gao, Xiang; Zhu, Shifa published their research in Chemical Science in 2021. The article was titled 《Dirhodium(II)-catalysed cycloisomerization of azaenyne: rapid assembly of centrally and axially chiral isoindazole frameworks》.Computed Properties of C4H7Br The article contains the following contents:
A dirhodium(II)-catalyzed asym. cycloisomerization reaction of azaenynes through a cap-tether synergistic modulation strategy, which represents the first catalytic asym. cycloisomerization of azaenynes. This reaction is highly challenging because of its inherent strong background reaction leading to racemate formation and the high capability of coordination of the nitrogen atom resulting in catalyst deactivation. Varieties of centrally chiral isoindazole derivatives was prepared in up to 99 : 1 d.r., 99 : 1 er and 99% yield and diverse enantiomerically enriched atropisomers bearing two five-membered heteroaryls was accessed by using an oxidative central-to-axial chirality transfer strategy. The tethered nitrogen atom incorporated into the starting materials enabled easy late-modifications of the centrally and axially chiral products via C-H functionalizations, which further demonstrated the appealing synthetic utilities of this powerful asym. cyclization.(Bromomethyl)cyclopropane(cas: 7051-34-5Computed Properties of C4H7Br) was used in this study.
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Computed Properties of C4H7Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary