Tsushima, Takumi; Tanaka, Hideya; Nakanishi, Kazuki; Nakamoto, Masaaki; Yoshida, Hiroto published an article in 2021. The article was titled 《Origins of Internal Regioselectivity in Copper-Catalyzed Borylation of Terminal Alkynes》, and you may find the article in ACS Catalysis.Safety of 1-Bromo-3,4,5-trimethoxybenzene The information in the text is summarized as follows:
Installation of a boron functionality into a more substituted carbon of terminal alkynes has been a challenging issue in chem. synthesis, since inherently Lewis acidic boron moieties, in principle, favor their attachment to a terminal carbon. Herein, we report on the highly internal-selective borylation of terminal alkynes under copper catalysis, wherein diminishment of boron-Lewis acidity and ligand-derived steric bulk around a copper center are the key to the success. In particular, the use of an anthranilamide-substituted boron moiety [B(aam)] is of high synthetic significance, because its properly diminished Lewis acidity enabled the internal regioselectivity and the Suzuki-Miyaura cross-coupling activity to be compatibly achieved. This method provided a direct and universal approach to variously substituted branched alkenylboron compounds, regardless of electronic and steric properties of a substituent on terminal alkynes. In the experiment, the researchers used many compounds, for example, 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Safety of 1-Bromo-3,4,5-trimethoxybenzene)
1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Safety of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary