Related Products of 52548-00-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 52548-00-2 as follows.
PREPARATIVE EXAMPLE 44; .Ph In aBH4; Step i; A mixture of 3-bromo-6-fluoro-o-xyle?e (25.37g, 432 mmol) in anhydrous CCI4 (250 mL) was treated with NBS (44.5g, 864 mmol) and benzoyl peroxide (310 mg) and then heated at reflux overnight. The mixture was cooled to 0 C and filtered, washing with hexanes. The filtrate was concentrated and chromatographed (hexanes) to give 44A as an colorless oil (41.57g, with minor mono-bromo impurities).
According to the analysis of related databases, 52548-00-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SCHERING CORPORATION; MCCORMICK, Kevin D.; DONG, Li; BOYCE, Christopher W; DE LERA RUIZ, Manuel; ZHENG, Junying; WON, Walter S.; WO2010/42475; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary