In 2017,Hong, Wei; Li, Jingyang; Chang, Zhe; Tan, Xiaoli; Yang, Hao; Ouyang, Yifan; Yang, Yanhui; Kaur, Sargit; Paterson, Ian C.; Ngeow, Yun Fong; Wang, Hao published 《Synthesis and biological evaluation of indole core-based derivatives with potent antibacterial activity against resistant bacterial pathogens》.Journal of Antibiotics published the findings.Safety of Methyl 3-(bromomethyl)benzoate The information in the text is summarized as follows:
The emergence of drug resistance in bacterial pathogens is a growing clin. problem that poses difficult challenges in patient management. To exacerbate this problem, there is currently a serious lack of antibacterial agents that are designed to target extremely drug-resistant bacterial strains. Here the authors describe the design, synthesis and antibacterial testing of a series of 40 novel indole core derivatives, which are predicated by mol. modeling to be potential glycosyltransferase inhibitors. Twenty of these derivatives were found to show in vitro inhibition of Gram-pos. bacteria, including methicillin-resistant Staphylococcus aureus. Four of these strains showed addnl. activity against Gram-neg. bacteria, including extended-spectrum β-lactamase producing Enterobacteriaceae, imipenem-resistant Klebsiella pneumoniae and multidrug-resistant Acinetobacter baumanii, and against Mycobacterium tuberculosis H37Ra. These four compounds are candidates for developing into broad-spectrum anti-infective agents. In the experiment, the researchers used many compounds, for example, Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Safety of Methyl 3-(bromomethyl)benzoate)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Safety of Methyl 3-(bromomethyl)benzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary