The author of 《Decorated Peptide Nanofibers with Cu Nanoparticles: An Efficient Catalyst for the Multicomponent Synthesis of Chromeno[2,3-d]pyrimidin-8-amines, Quinazolines and 2H-Indazoles》 were Taherinia, Zahra; Ghorbani-Choghamarani, Arash; Hajjami, Maryam. And the article was published in ChemistrySelect in 2019. Safety of o-Bromobenzaldehyde The author mentioned the following in the article:
An efficient, simple and green protocol was developed for the synthesis of 7,10-diaryl-7H-benzo[7,8]chromeno[2,3-d]pyrimidin-8-amines I (R1 = Ph, 2-ClC6H4, 4-HOC6H4, etc.), 2-R2-substituted indazoles (R2 = Ph, 4-MeC6H4, 2,4-Cl2C6H3, etc.) and 2-R3-substituted quinazolines (R3 = Ph, 4-MeOC6H4) in the presence of peptide nanofibers decorated with Cu nanoparticles. Peptide nanofiber was synthesized by self-assembly technique. The effect of succinic anhydride was evaluated in two conditions: (i) without adding succinic anhydride at pH 4, (ii) by adding succinic anhydride at pH 5. Synthesized peptide nanofiber was characterized by 1H, 13C, DEPT NMR spectroscopies (Distortionless enhancement by polarization transfer), CHNSO, SEM, fluorescence spectroscopy, UV/Vis, FTIR and transmission electron microscopy (TEM). The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Safety of o-Bromobenzaldehyde)
o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Safety of o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary