Formula: C6H5Br2NIn 2017 ,《Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions》 was published in Organic Letters. The article was written by Rojas, Anthony J.; Pentelute, Bradley L.; Buchwald, Stephen L.. The article contains the following contents:
Authors report the use of a sulfonated biarylphosphine ligand (sSPhos) to promote the chemoselective modification of cysteine containing proteins and peptides with palladium reagents in aqueous medium. The use of sSPhos allowed for the isolation of several air-stable and water-soluble mono- and bis-palladium reagents, which were used in an improved protocol for the rapid S-arylation of cysteines under benign and physiol. relevant conditions. The cosolvent-free aqueous conditions were applied to the conjugation of a variety of biomols. with affinity tags, heterocycles, fluorophores, and functional handles. Addnl., bis-palladium reagents were used to perform macrocyclization of peptides bearing two cysteine residues. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Formula: C6H5Br2N)
3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Formula: C6H5Br2N
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary