Related Products of 1647-26-3, These common heterocyclic compound, 1647-26-3, name is 1-Bromo-2-cyclohexylethane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Amines 6 (1.0 equivalent) were added to solutions of alkyl halides (1.0 equivalents) in DMF (10ml per gram of 6), followed by TEA (1 .1 equivalents) and the mixture microwaved 60 C for 1 h or until complete consumption of starting materials. The reactions were monitored by TLC using either MeOH:CHCl3 or EA:HEX mixtures and PMA staining. Upon completion, the reaction mixtures were diluted with 15% IPA in CHCI3 (10vol), washed with 1 N NaOH (1vol), dried with Na2S04, filtered and the solvents removed in vacuo. The crude products were purified by FC on silica gel using suitable solvent mixtures from MeOH:CHCl3 or EA:HEX depending on TLC conditions. For highly polar compounds, TEA was added in the mobile phase at concentrations anywhere from 0.1 to 1 %. Product purity was determined by HPLC and product identity confirmed by LC-MS (ESI+) and/or 1H NMR. Alternately, a more convenient work-up procedure was developed by diluting reaction mixture with DMF (1 vol) and stirring with AS-900 (OH-) resin (5g of resin per gram of 6) for 1 h, filtered and the solvents removed in vacuo to give crude product which is purified further.
The synthetic route of 1647-26-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNILEVER PLC; UNILEVER N.V.; CONOPCO, INC., D/B/A UNILEVER; ROSA, Jose, Guillermo; LEE, Jianming; MARRERO, Diana; ADAMUS, Jean, Elizabeth; VILLA-MORA, Stella; (51 pag.)WO2016/173817; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary