Product Details of 626-40-4In 2019 ,《Experimental and theoretical investigations of cyclometalated ruthenium(II) complex containing CCC-pincer and anti-inflammatory drugs as ligands: synthesis, characterization, inhibition of cyclooxygenase and in vitro cytotoxicity activities in various cancer cell lines》 was published in Dalton Transactions. The article was written by Tabrizi, Leila; Olasunkanmi, Lukman O.; Fadare, Olatomide A.. The article contains the following contents:
The new cyclometalated ruthenium(II) complex, [Ru(CCC-Nap)(Ibu)(PTA)], I (3), was designed and synthesized using ibuprofen (Ibu), 1,3,5-triaza-7-phosphaadamantane (PTA) and CCC-pincer containing naproxen moiety (CCC-Nap) as ligands. The compounds were fully characterized by elemental anal., FT-IR, multinuclear (1H, 13C, and 31P) NMR spectroscopy, and electrospray ionization mass spectrometry. The cytotoxicity of 3 was found to be low, and the complex was about twice as active as cisplatin with IC50 values in the range of 0.9-1.32 μM for both MCF-7 and MDA-MB-231 cell lines. Cyclooxygenase (COX) inhibition studies revealed that 3 displayed strong interactions with COX-2, about 16 and 5 times more than free Ibu and CCC-Nap ligands, resp. The complex 3 improved the production of reactive oxygen species (ROS) by 10.7 fold compared to the control (H2O2 as a pos. control) in MCF-7 cells. Quantum chem. calculations gave more insights into the geometry and electronic properties of the novel complex 3, while mol. docking provided theor. information on the interactions of 3 with human cyclooxygenase-2 (COX-2) and the results were compared with those of the interactions of the free ligands with COX-2. In the experiment, the researchers used many compounds, for example, 3,5-Dibromoaniline(cas: 626-40-4Product Details of 626-40-4)
3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Product Details of 626-40-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary