Formula: C10H16Br3NOn March 2, 2021, Williams, Sierra J.; Hwang, Clare S.; Prescher, Jennifer A. published an article in Biochemistry. The article was 《Orthogonal bioluminescent probes from disubstituted luciferins》. The article mentions the following:
Bioluminescence imaging with luciferase-luciferin pairs is routinely used to monitor cellular functions. Multiple targets can be visualized in tandem using luciferases that process unique substrates, but only a handful of such orthogonal probes are known. Multiplexed studies require addnl. robust, light-emitting mols. In this work, we report new luciferins for orthogonal imaging that comprise disubstituted cores. These probes were found to be bright emitters with various engineered luciferases. The unique patterns of light output also provided insight into enzyme-substrate interactions necessary for productive emission. Screening studies identified mutant luciferases that could preferentially process the disubstituted analogs, enabling orthogonal imaging with existing bioluminescent reporters. Further mutational analyses revealed the origins of substrate selectivity. Collectively, this work provides insights into luciferase-luciferin features relevant to bioluminescence and expands the number of probes for multicomponent tracking. The results came from multiple reactions, including the reaction of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide(cas: 111865-47-5Formula: C10H16Br3N)
Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide(cas: 111865-47-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Formula: C10H16Br3N
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary