《Amidoxime-Functionalized Covalent Organic Nanosheets for Sequestration of Uranium In Vivo》 was published in ACS Applied Bio Materials in 2020. These research results belong to Chen, Long; Bai, Ru; Wang, Xiaomei; Zhang, Yijing; He, Linwei; Zhang, Mingxing; Chong, Yu; Chai, Zhifang; Wang, Xiao-Feng; Diwu, Juan. Quality Control of 1,4-Bis(bromomethyl)benzene The article mentions the following:
Finding efficient actinide decorporation agents is crucial for public health and the development of the nuclear industry. The current inventory of decorporation agents is predominately limited to a handful of ligands. In this work, a two-dimensional (2D) covalent organic nanosheet (CON) material was rationally designed and tested for in vivo uranium decorporation. This material is extensively grafted with amidoxime (AO), a classic uranium-recognition ligand, which not only provides selective binding sites for uranyl but also expands the interlayer spacing of CON, making the active sites more accessible. Significantly, the results of in vivo experiments demonstrate that, in both prophylactic and prompt administration groups, CON-AO exhibits a higher excretion ratio of uranium from kidneys than that of ZnNa3-diethylenetriamine pentaacetate (DTPA), while presenting a similar level of cytotoxicity. These results suggest that functionalized CONs may emerge as a promising type of actinide in vivo decorporation agent. In the part of experimental materials, we found many familiar compounds, such as 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Quality Control of 1,4-Bis(bromomethyl)benzene)
1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Quality Control of 1,4-Bis(bromomethyl)benzene Organobromine compounds have fallen under increased scrutiny for their environmental impact.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary