《Access to 12-membered cyclic ortho,meta-diarylheptanoids: total synthesis of Actinidione via Isomyricanone》 was written by Masse, Paul; Choppin, Sabine; Chiummiento, Lucia; Colobert, Francoise; Hanquet, Gilles. Synthetic Route of C9H11BrO3This research focused ontwelve membered cyclic ortho meta diarylheptanoid synthesis; Suzuki Miyaura coupling ring closing metathesis; Actinidione synthesis Isomyricanone. The article conveys some information:
We describe herein the first access to 12-membered cyclic[7,0]ortho,meta-diarylheptanoids. The key features of the synthesis include both a Suzuki-Miyaura coupling and a ring closing metathesis. Actinidione, a promising natural product, along with a bioactive tetracyclic derivative were obtained in 14 steps for the first time from cheap com. available substrates with an overall yield of 18-21%. Our modus operandi complies with the principles of the synthesis ideality by using notably strategic reactions. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Synthetic Route of C9H11BrO3)
1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Synthetic Route of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary