《Synthesis of Novel Vindoline-Chrysin Hybrids》 was written by Mayer, Szabolcs; Nagy, Nora; Keglevich, Peter; Szigetvari, Aron; Dekany, Miklos; Szantay, Csaba Junior; Hazai, Laszlo. COA of Formula: C4H7BrO2This research focused onvindoline chrysin doxorubicin cisplatin ciglitazone diphenylamine 10 chloroacetamidovindoline anticancer; anticancer effect; chrysin; hybrid molecule; reaction mechanism; vindoline. The article conveys some information:
Vinca alkaloids are well-known microtubule targeting agents, which are used against some types of cancer. Vindoline is one of the monomeric Vinca alkaloids which does not have anti-tumor effect, although its derivatives have serious impact on the field of these indole alkaloids. Chrysin is a secondary plant metabolite, which has broad-spectrum biol. activity, among others anticancer activity. Chrysin had shown synergic effect with several antiproliferative compounds (e. g., doxorubicin, cisplatin and ciglitazone), therefore, we attempted the synthesis of a novel vindoline-chrysin hybrid mol. However, in the first case a diphenylamine structure was isolated. The mechanism of the unexpected reaction was studied, and then the originally targeted hybrid was synthesized by a reverse route coupling. A further hybrid was produced using a different site of the mol. The antitumor activities were determined against 60 human tumor cell lines (NCI60), where the aimed hybrid showed low micromolar GI50 values on most of the cell lines. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2COA of Formula: C4H7BrO2) was used in this study.
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).COA of Formula: C4H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary