In 2017,Jiang, Yan; Zhuang, Chunlin; Chen, Long; Lu, Junjie; Dong, Guoqiang; Miao, Zhenyuan; Zhang, Wannian; Li, Jian; Sheng, Chunquan published 《Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors》.Journal of Medicinal Chemistry published the findings.Recommanded Product: 3395-91-3 The information in the text is summarized as follows:
Structural biol. is a powerful tool for investigating the stereospecific interactions between a protein and its ligand. Herein, an unprecedented chiral binding pattern was observed for inhibitors of KRAS-PDEδ interactions. Virtual screening and X-ray crystallog. studies revealed that two enantiomers of a racemic inhibitor could bind at different sites. Fragment-based drug design was used to identify highly potent PDEδ inhibitors that can be used as promising lead compounds for target validation and antitumor drug development. The results came from multiple reactions, including the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Recommanded Product: 3395-91-3)
Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: 3395-91-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary