In 2018,Organometallics included an article by Martinez, Gabriel Espinosa; Nugent, Joseph W.; Fout, Alison R.. Category: bromides-buliding-blocks. The article was titled 《Simple Nickel Salts for the Amination of (Hetero)aryl Bromides and Iodides with Lithium Bis(trimethylsilyl)amide》. The information in the text is summarized as follows:
Recent developments in the chem. of C-N bond formation and the synthesis of anilines have allowed for the use of 1st-row transition metals to catalyze these transformations. Much of the progress in this area was driven by comprehensive screening for privileged/tailored ligands, which can be costly and not readily available in a research laboratory setting. The authors report a protocol in which simple Ni salts catalyze the C-N cross-coupling reaction between (hetero)aryl bromides and iodides with Li bis(trimethylsilyl)amide without the need for any additive ligand. This method is amenable to low Ni catalyst loadings (1%) as well as gram-scale reactions. Because of the good functional group tolerance and compatibility with heterocyclic moieties, this method is useful for academic laboratory settings where access to tailored ligands and noble-metal catalysts could be challenging. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Category: bromides-buliding-blocks)
3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary