In 2019,New Journal of Chemistry included an article by Zare, Abdolkarim; Kohzadian, Alireza; Abshirini, Zahra; Sajadikhah, Seyed Sajad; Phipps, Joshua; Benamara, Mourad; Beyzavi, M. Hassan. Product Details of 6630-33-7. The article was titled 《Nano-2-(dimethylamino)-N-(silica-n-propyl)-N,N-dimethylethanaminium chloride as a novel basic catalyst for the efficient synthesis of pyrido[2,3-d:6,5-d’]dipyrimidines》. The information in the text is summarized as follows:
This study describes the synthesis and characterization of nano-2-(dimethylamino)-N-(silica-n-propyl)-N,N-dimethylethanaminium chloride {nano-[DMSPDE][Cl]}, and its application as a highly effective, heterogeneous and recyclable basic catalyst for the promotion of a useful organic reaction. The catalyst was characterized using FTIR, SEM, TEM, TGA, XRD, Brunauer-Emmett-Teller (BET) and energy-dispersive x-ray spectroscopy (EDS) methods. The nanocatalyst was used to facilitate the solvent-free preparation of pyrido[2,3-d:6,5-d’]dipyrimidines by the multi-component reaction of 2-thiobarbituric acid, arylaldehydes and NH4OAc. Nano-[DMSPDE][Cl] furnished the products in high yields and in short reaction times, and showed no significant loss of activity after multiple runs. In the literature, pyrido[2,3-d:6,5-d’]dipyrimidines were synthesized using Lewis or acidic catalysts; however, a basic catalyst was applied for their preparation In the experiment, the researchers used many compounds, for example, o-Bromobenzaldehyde(cas: 6630-33-7Product Details of 6630-33-7)
o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Product Details of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary