On March 28, 2013, Culcasi, Marcel; Casano, Gilles; Lucchesi, Celine; Mercier, Anne; Clement, Jean-Louis; Pique, Valerie; Michelet, Laure; Krieger-Liszkay, Anja; Robin, Maxime; Pietri, Sylvia published an article.SDS of cas: 83152-22-1 The title of the article was Synthesis and Biological Characterization of New Aminophosphonates for Mitochondrial pH Determination by 31P NMR Spectroscopy. And the article contained the following:
A series of mitochondria targeted α-aminophosphonates combining a diethoxyphosphoryl group and an alkyl chain-connected triphenylphosphonium bromide tail were designed and synthesized, and their pH-sensitive 31P NMR properties and biol. activities in vitro and in vivo were evaluated. The results showed a number of these mito-aminophosphonates exhibiting pKa values fitting the mitochondrial pH range, short relaxation, and chem. shift parameters compatible with sensitive 31P NMR detection, and low cytotoxicity on green algae and murine fibroblasts cell cultures. Of these, two selected compounds demonstrated to distribute at NMR detectable levels within the cytosolic and mitochondrial sites following their perfusion to isolated rat livers, with no detrimental effects on cell energetics and aerobic respiration. This study provided a new mol. scaffold for further development of in situ spectroscopic real-time monitoring of mitochondrion/cytosol pH gradients. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).SDS of cas: 83152-22-1
The Article related to aminophosphonate mitochondria ph phosphorus nmr spectroscopy, Biochemical Methods: Spectral and Related Methods and other aspects.SDS of cas: 83152-22-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary