On January 14, 2021, Garofalo, Albert W.; De Lombaert, Stephane; Schwarz, Jacob Bradley; Andreotti, Daniele; Sabbatini, Fabio Maria; Serra, Elena; Bernardi, Silvia; Migliore, Marco; Budassi, Federica; Beato, Claudia published a patent.Related Products of 1427433-22-4 The title of the patent was Indazoles and azaindazoles as LRRK2 inhibitors in the treatment of CNS disorders and their preparation. And the patent contained the following:
The invention relates compounds of formula I, their preparation and their use as inhibitors of LRRK2 in the treatment of CNS disorders. Compound I, wherein A is halo, (un)subsititued C1-6 alkyl, (un)subsititued C2-6 alkenyl, etc.; ring B is Ph and 5- to 10-membered heteroaryl wherein said 5- to 10-membered heteroaryl comprises 1, 2 and 3 ring-forming heteroatoms independently864 selected from N, O and S; X2 is N and CR2; X3 is N and CR3; X4 is N and CR4; no more than two of X2, X3 and X4 are simultaneously N; R1 is independently H, halo, C1-6 alkyl, etc.; R2 and R4 are independently H, halo, C2-6 alkenyl, etc.; R3 is H, halo, C1-6 haloalkyl, etc.; n is 0, 1, 2, and 3; and pharmaceutically acceptable salts thereof, are claimed. Compound II was prepared by reacting 3-bromo-1H-indazol-5-amine with 3-furanylboronic acid yielding 3-(furan-3-yl)-1H-indazole-5-amine, then 5-cyano-3-fluoropyridine-2-carboxylic acid underwent amidation with 3-(furan-3-yl)-1H-indazole-5-amine to yield compound II. Compound II was evaluated for LRRK2 inhibitory activity resulting in a wild type LRRK2 and G2019S LRRK2 IC50 of ≤ 100 nM for both. Compounds of the invention were evaluated for their LRRK2 inhibitory activity (data given). The experimental process involved the reaction of 3-Bromo-2-fluoro-6-methyl-benzoic acid(cas: 1427433-22-4).Related Products of 1427433-22-4
The Article related to indazole azaindazole preparation lrrk2 inhibitor cns disorder, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Related Products of 1427433-22-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary