On June 4, 2020, Guillemont, Jerome Emile Georges; Lancois, David Francis Alain; Chao, Sovy; Angibaud, Patrick Rene; Mercey, Guillaume Jean Maurice; Raboisson, Pierre Jean-Marie Bernard; Michaut, Antoine Benjamin; Rigaux, Peter published a patent.Name: 3-Bromo-2-fluoro-6-methoxybenzaldehyde The title of the patent was Further heteroaromatic compounds having activity against RSV and their preparation. And the patent contained the following:
The invention concerns compounds of formula I having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment or prevention of respiratory syncytial virus infection. Compounds of formula I wherein A is substituted 1,2,3,4-tetrahydroisoquinolinyl, substituted azepanyl, amino, etc.; R5 is substituted Ph, substituted pyridinyl, substituted benzopyranyl, etc.; R15 is H and C1-4 alkyl; X1, X2 and X3 are independently N and CR; R is H and C1-4 alkyl; with provisions; and stereochem. isomeric forms thereof, are claimed. Example compound II was prepared by carboxylation of 4-(8-cyclopropyl-6-[(1R)-1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]imidazo[1,2-a]pyridin-2-yl)-3-fluorobenzoic acid. The invention compounds were evaluated for their antiviral activity. From the assay, it was determined that compound II exhibited EC50 value of 0.510μM and a CC50 value of 60.4μM. The experimental process involved the reaction of 3-Bromo-2-fluoro-6-methoxybenzaldehyde(cas: 1160653-94-0).Name: 3-Bromo-2-fluoro-6-methoxybenzaldehyde
The Article related to heteroaromatic preparation treatment rsv infection antiviral, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Name: 3-Bromo-2-fluoro-6-methoxybenzaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary