Polymer-supported bases, 4. Macrolide synthesis from 闁?bromocarboxylic acids using polymer-supported 1,8-diazabicyclo[5.4.0]undec-7-ene was written by Tomoi, Masao;Watanabe, Takashi;Suzuki, Takayuki;Kakiuchi, Hiroshi. And the article was included in Makromolekulare Chemie in 1985.Formula: C15H29BrO2 This article mentions the following:
The macrolide yield in the title synthesis is a function of the degree of ring substitution and of crosslinking, which governs the effective concentration of the fixed substrate within the polymeric reagent. The effect of the polystyrene matrix on the macrolide yield in the heterogeneous system was compared with the corresponding homogeneous reaction. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Formula: C15H29BrO2).
15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C15H29BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary